{"id":20581,"date":"2022-10-25T19:53:16","date_gmt":"2022-10-25T19:53:16","guid":{"rendered":"https:\/\/peymantaeidi.net\/stem-cell\/?p=20581"},"modified":"2022-10-25T20:05:40","modified_gmt":"2022-10-25T20:05:40","slug":"invisible-diamonds-that-will-soon-replace-injections","status":"publish","type":"post","link":"https:\/\/peymantaeidi.net\/stem-cell\/2022\/10\/25\/invisible-diamonds-that-will-soon-replace-injections\/","title":{"rendered":"Invisible Diamonds That Will Soon Replace Injections"},"content":{"rendered":"

New generation of medication to be absorbed through the skin<\/h3>\n

Researchers are using nanodiamonds to create a new generation of medication, which will be absorbed through the skin.<\/p>\n

Tiny particles of carbon \u2013 measuring just a millionth of a millimeter \u2013 will offer a safe and pain-free alternative to injections.<\/p>\n

Through-skin technology is already widely used in patches for nicotine, caffeine, contraception, pain relief and more. But to treat specific skin layers drug developers need to understand their \u201cpermeation profiles\u201d, or how the particles behave as they pass through the skin.<\/p>\n

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Magnified nanodiamonds penetrate all layers of skin. Credit: Prof. Dror Fixler<\/figcaption><\/figure>\n

Drug companies are developing new treatments, using invisible particles coated with medicine, but they need to know exactly which part of the skin they reach, to know whether they will work effectively.<\/p>\n

A team at Israel\u2019s Bar-Ilan University, near Tel Aviv, has made a breakthrough discovery that allows them to precisely track the movement of the particles, as never before.<\/p>\n

Its laser-based system indicates whether the nanodiamonds are in the right place and in the right concentrations for through-the-skin treatments to work.<\/p>\n

Without the lasers, drug developers carrying out clinical trials have had to take biopsies \u2013 an invasive and sometimes painful technique in which cells or tissue are removed \u2013 to see whether the nanodiamonds had reached their target.<\/p>\n

\u201cThis is a significant development in dermatology and in optical engineering,\u201d said Prof Dror Fixler<\/a>, Director of the Institute of Nanotechnology and Advanced Materials at Bar-Ilan.<\/p>\n

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Measuring how nanodiamonds are absorbed by pig skin. Credit: Prof. Dror Fixler<\/figcaption><\/figure>\n

\u201cIt could open the door to developing drugs applied through the skin alongside modern cosmetic preparations using advanced nanotechnology.\u201d<\/p>\n

Nanodiamonds are a very recent innovation. They are produced at the university\u2019s chemistry department by detonating explosives inside a closed chamber. <\/p>\n

That replicates the high-pressure, high-temperature conditions under which natural diamonds are formed below the earth\u2019s surface.<\/p>\n

The nanodiamonds are then applied to the skin as a solution \u2013 a very fine powder mixed with a few drops of water. In lab experiments the team used pig skin, then measured the progress of the nanodiamonds after three hours.<\/p>\n

The tricky bit is tracking something that measures just a millionth of a millimeter. It\u2019s hard enough in any circumstance, but the skin tissue is turbid \u2013 opaque and hard to see through. <\/p>\n

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