{"id":25894,"date":"2022-11-23T22:32:13","date_gmt":"2022-11-23T23:32:13","guid":{"rendered":"https:\/\/peymantaeidi.net\/stem-cell\/?p=25894"},"modified":"2022-11-24T00:37:04","modified_gmt":"2022-11-24T00:37:04","slug":"bacteria-use-ancient-mechanisms-to-self-repair","status":"publish","type":"post","link":"https:\/\/peymantaeidi.net\/stem-cell\/2022\/11\/23\/bacteria-use-ancient-mechanisms-to-self-repair\/","title":{"rendered":"Bacteria use ancient mechanisms to self-repair"},"content":{"rendered":"
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A new study led by UNSW Sydney<\/a> scientists unveils how nature’s oldest wheel, found within bacteria, can fix itself when times get tough.<\/p>\n

The findings, published today in Science Advances<\/a><\/em>, show how the flagellar\u2014the ancient motor that powers the swimming ability of bacteria\u2014can also help these tiny organisms adjust to conditions where their motility is impaired.<\/p>\n

Bacteria are one of Earths\u2019 oldest living organisms. They are tiny single-celled organisms found across every habitat, including the human body\u2014where there are more bacterial cells than human cells.<\/p>\n

Being able to swim is crucial to how bacteria survive and spread. But little is known about how the motors that drive their movement help the organisms adapt to hostile environments.<\/p>\n

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Read more: Local bacteria help native seeds take root in arid landscapes<\/a><\/strong><\/em><\/p>\n<\/blockquote>\n

The researchers from the School of Biotechnology and Biomolecular Sciences<\/a> are the first in the world to use CRISPR gene-editing technology to alter a flagellar motor. They used synthetic biology techniques to engineer a sodium motor onto the genome to create a sodium-driven swimming bacteria. They then tested and tracked the bacteria\u2019s ability to adapt when the environment was starved of sodium.<\/p>\n

Sodium is an ion, which means that it carries a charge. It is this charge that powers the flagellar motor via stators, or ion channels.<\/p>\n

The team found that the stators were able to rapidly self-repair the flagellar motor and restore movement. These findings could lead to new advances across the biological and medical science fields.<\/p>\n

\u201cWe showed that environmental changes can cause ion channels to react quickly,\u201d said lead author of the paper Dr Pietro Ridone.<\/p>\n

\u201cSo, the CRISPR edits also revert quickly, and the flagellar motor evolves and then regulates itself,\u201d Dr Ridone said.<\/p>\n

\u201cThe fact that we saw mutations directly on the stators right away is surprising, and also inspires a lot of our future research plans in this area.\u201d<\/p>\n

The power of molecular machinery<\/h2>\n

The human body contains around 10,000 different types of molecular machines, which power a range of biological functions from energy conversion to movement.<\/p>\n

The technology of a bacterial motor far surpasses what humans can synthetically engineer at nanoscale. At a millionth the size of a grain of sand, it can assemble itself and rotates at up to five times the speed of a Formula 1 engine.<\/p>\n

\u201cThe motor that powers bacterial swimming is a marvel of nanotechnology,\u201d said Associate Professor Matthew Baker, a co-author of the paper. \u201cIt is the absolute poster child for ancient and very sophisticated molecular machinery.\u201d<\/p>\n

A\/Prof. Baker said the study\u2019s findings can help us better understand the origin of molecular motors in mechanistic detail\u2014how they came together and how do they adapt.<\/p>\n

\u201cThese ancient parts are a powerful system to study evolution in general, as well as the origins and evolution of motility.\u201d<\/p>\n

A\/Prof. Baker says the findings will inform how synthetic biology can help create new molecular motors. The findings may also have applications in understanding antimicrobial resistance and the virulence of disease.<\/p>\n

\u201cBy shedding more light on life\u2019s ancient history, we are gaining knowledge to create tools that can help better our futures,\u201d A\/Prof. Baker said. \u201cIt can also lead us to insights on how bacteria might adapt under future climate change scenarios.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

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