{"id":29969,"date":"2022-12-11T21:22:35","date_gmt":"2022-12-11T22:22:35","guid":{"rendered":"https:\/\/peymantaeidi.net\/stem-cell\/?p=29969"},"modified":"2022-12-11T22:35:26","modified_gmt":"2022-12-11T22:35:26","slug":"researchers-infect-a-brain-in-a-dish-in-search-for-zika-antivirals","status":"publish","type":"post","link":"https:\/\/peymantaeidi.net\/stem-cell\/2022\/12\/11\/researchers-infect-a-brain-in-a-dish-in-search-for-zika-antivirals\/","title":{"rendered":"Researchers infect a \u2018brain in a dish\u2019 in search for Zika antivirals"},"content":{"rendered":"
\"image\"<\/div>\n

A University of Queensland-led project has used a \u2018brain in a dish\u2019 to study the effects of the Zika virus, taking research a step closer towards developing drugs to combat the infection.<\/span><\/span><\/span><\/span><\/p>\n

The mosquito-borne Zika virus is found in 89 countries and can penetrate the placenta of a pregnant mother to infect her baby, causing severe brain abnormalities.<\/span><\/span><\/span><\/span><\/p>\n

Dr Andrii Slonchak<\/span><\/a> and <\/span>Dr Alexander Khromykh<\/span><\/a> from UQ\u2019s <\/span>School of Chemistry and Molecular Biosciences<\/span><\/a> found a crucial element to Zika infection, viral noncoding RNA (sfRNA), helps it evade antiviral responses and cause cell-death in developing brains.<\/span><\/span><\/span><\/span><\/p>\n

\u201cIt\u2019s a little like something out of a science fiction movie \u2013 we\u2019re growing an artificial and microscopic human brain in a petri dish and testing the effect of the virus on its cells,\u201d Dr Slonchak said.<\/span><\/span><\/span><\/span><\/p>\n

\u201cStem cells self-organise into organ-like structures, or organoids, and in this case they have the structure and tissue architecture of the developing human brain.<\/span><\/span><\/span><\/span><\/p>\n

\u201cOur study shows the role of viral noncoding RNA in transplacental infection in pregnant mice and in cell death in human brain organoids.<\/span><\/span><\/span><\/span><\/p>\n

\u201cThis finding gives us a whole new look at how the virus works its way into the developing brain and knowledge we can use to develop more effective antiviral drugs.\u201d<\/span><\/span><\/span><\/span><\/p>\n

Dr Khromykh said while the number of recorded cases of Zika may seem low, at round 1.3 million in total globally, its impact warrants urgent attention.<\/span><\/span><\/span><\/span><\/p>\n

\u201cZika can cause significant abnormalities in babies, so there\u2019s a race to understand how it works and how to stop it,\u201d Dr Khromykh said.<\/span><\/span><\/span><\/span><\/p>\n

\u201cAbnormalities can include optic nerve damage, smaller than expected head sizes, problems in the area of the brain that connects the two hemispheres and wasting of tissue in critical brain regions.<\/span><\/span><\/span><\/span><\/p>\n

\u201cNo cases of Zika-related birth defects have been reported in Australia, but given the unpredictable nature of viral outbreaks and the endemic nature of Zika in the Oceanic region, it very well might strike and we should be prepared for it.\u201d<\/span><\/span><\/span><\/span><\/p>\n

The next step for researchers is to further understand how a specific viral protein, NS5, interacts with sfRNA at the molecular level and how this interaction helps the virus to escape antiviral response.<\/span><\/span><\/span><\/span><\/p>\n

\u201cThis information will help researchers develop antiviral drugs to block this interaction and combat Zika,\u201d Dr Khromykh said.<\/span><\/span><\/span><\/span><\/p>\n

This study was a collaborative effort between researchers at UQ\u2019s School of Chemistry and Molecular Biosciences<\/a> and Australian Institute for Bioengineering and Nanotechnology<\/a> (AIBN) and the QIMR Berghofer Medical Research Institute.<\/span><\/span><\/span><\/span><\/p>\n

This research is published in Science Advances<\/i><\/a>.<\/span><\/span><\/span><\/span><\/p>\n

Media: Dr Andrii Slonchak, a.slonchak@uq.edu.au<\/a>, +61 (0)402 184 626, Dr Alexander Khromykh, a.khromykh@uq.edu.au<\/a>, +61 (0)434 367 342; <\/span><\/b><\/span><\/span><\/span>UQ Communications, <\/span><\/span><\/span><\/span><\/span><\/strong>communications@uq.edu.au<\/span><\/span><\/span><\/span><\/span><\/strong><\/a>, +61 (0)429 056 139.<\/span><\/span><\/span><\/strong><\/span><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

A University of Queensland-led project has used a \u2018brain in a dish\u2019 to study the<\/p>\n","protected":false},"author":1,"featured_media":29971,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/posts\/29969"}],"collection":[{"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/comments?post=29969"}],"version-history":[{"count":2,"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/posts\/29969\/revisions"}],"predecessor-version":[{"id":29972,"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/posts\/29969\/revisions\/29972"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/media\/29971"}],"wp:attachment":[{"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/media?parent=29969"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/categories?post=29969"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/tags?post=29969"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}