![\"Histidine](\"https:\/\/peymantaeidi.net\/stem-cell\/wp-content\/uploads\/2022\/12\/22ff847a-0639-4ecc-a649-ae5d5eacb18a.jpg\")
<\/figure>\nHistidine<\/a>, a versatile proteinogenic amino acid<\/a>, plays a broad range of roles in all living organisms and behaves as a key mediator of the interactions of biomolecules<\/a> with inorganic constituents<\/a>. The self-assembly of histidine-rich peptides<\/a> and proteins is critical in biology, as the histidine unit is both a multifunctional regulator and an ideal motif for the construction of complex biological structures. In particular, non-covalent interactions between the imidazole<\/a> ring and other molecular building blocks and metal ions<\/a> are routinely employed to generate these complexes. Therefore, this strategy can be duplicated in an artificial context to create sophisticated bioactive materials<\/a>. In this review, we first highlight a clear perspective of the bio-inspired design strategies which can replicate the hierarchical structure of biological systems allowing the engineering of the supramolecular self-assembly of histidine-functionalized peptides. We further summarize advancements in the field of peptide supramolecular structures<\/a> incorporating histidine residues<\/a> in the peptide backbone to generate organized functional supramolecular biomaterials with customizable features. We also discuss significant advances and future prospects in supramolecular self-assembly of histidine-functionalized peptides, as well as provide an overview of advanced techniques for the fabrication of histidine-based biomaterials for bio-nanotechnology, optoelectronic<\/a> engineering, and biomedicine. Overall, artificial supramolecular materials<\/a> based on histidine functionalized peptides, motivated by the intriguing properties discovered in natural proteins, bear the potential to boost the creation of sustainable bio-inspired materials.<\/p>\n<\/figure>\n