{"id":46154,"date":"2023-03-27T18:15:58","date_gmt":"2023-03-27T18:15:58","guid":{"rendered":"https:\/\/peymantaeidi.net\/stem-cell\/?p=46154"},"modified":"2023-03-27T18:38:10","modified_gmt":"2023-03-27T18:38:10","slug":"a-father-had-a-heart-attack-at-56-his-sons-technology-couldve-predicted-it","status":"publish","type":"post","link":"https:\/\/peymantaeidi.net\/stem-cell\/2023\/03\/27\/a-father-had-a-heart-attack-at-56-his-sons-technology-couldve-predicted-it\/","title":{"rendered":"A father had a heart attack at 56. His son\u2019s technology could\u2019ve predicted it"},"content":{"rendered":"
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He used the tools to study how the mechanical forces of heart contractions, blood flow and pressure can activate platelets, the disc-shaped blood cells that clump together and cause clots.<\/p>\n

\u201cBy poking or pushing this single platelet, which is about two micron [two millionths of a metre] in size, we can observe the platelet\u2019s response to different forces,\u201d he said.<\/p>\n

\u201cAll these mechanical forces in our system are very critical, but there\u2019s no available technologies to help elucidate how these forces trigger clotting.\u201d <\/p>\n

Armed with a greater understanding of how platelets and other blood cells behave before a stroke or heart attack, Ju started developing a blood test that can produce results in as little as 10 minutes to inform whether someone needs to go to hospital or take blood thinners.<\/p>\n

The goal of his research is to create a hand-held device similar to at-home blood sugar tests used by people with diabetes. A 3D-printed testing chip could also be incorporated into a cassette resembling a rapid antigen test.<\/p>\n<\/div>\n

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The chip would test for the three elements of blood clotting \u2013 hypercoagulation or \u201cstickiness\u201d in the blood, damage to vessel walls and interrupted blood flow.<\/p>\n

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\"Arnold<\/div>
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Arnold Ju at work in his lab in Sydney.<\/span>Credit:<\/span>Jessice Hromas<\/cite><\/p>\n<\/figcaption><\/figure>\n

\u201cThe COVID rapid antigen test really saved the burden for the NSW healthcare system,\u201d Ju said. \u201cWe could use nanotechnologies, microtechnologies, to miniaturise the blood clotting test.<\/p>\n

\u201cThat is the dream; you want to build everything into a cassette and then you can manipulate cells, apply forces, and sense the cell\u2019s response in one go.\u201d<\/p>\n

Using artificial technology, his team are planning to create personalised blood profiles to more accurately detect microscopic changes in someone\u2019s blood cells and tailor treatment to individual patients.<\/p>\n<\/div>\n

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Ju hopes the device, paired with AI-powered diagnosis, could help alleviate healthcare inequality by more easily treating people who live far away from hospitals and health services.<\/p>\n

The technology could one day be used to monitor his father, who survived the heart attack and surgery but still has cardiovascular problems.<\/p>\n

Ju is the first engineer or physicist to be awarded medical research funding under the Snow Fellowship, a decision he welcomed.<\/p>\n

\u201cThis is not just something that you can solve with one discipline,\u201d he said. \u201cDoctors are still using the technology that\u2019s been there for 30 or 40 years. And the physicists are studying their problems already defined 20 or 30 years ago.<\/p>\n<\/div>\n

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\u201cI think I\u2019ve been lucky and well-trained to know the language from both sides.\u201d<\/p>\n

The Morning Edition newsletter is our guide to the day\u2019s most important and interesting stories, analysis and insights. <\/i><\/b>Sign up here<\/i><\/b><\/a>.<\/i><\/b><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

He used the tools to study how the mechanical forces of heart contractions, blood flow<\/p>\n","protected":false},"author":1,"featured_media":46156,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/posts\/46154"}],"collection":[{"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/comments?post=46154"}],"version-history":[{"count":2,"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/posts\/46154\/revisions"}],"predecessor-version":[{"id":46157,"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/posts\/46154\/revisions\/46157"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/media\/46156"}],"wp:attachment":[{"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/media?parent=46154"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/categories?post=46154"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/peymantaeidi.net\/stem-cell\/wp-json\/wp\/v2\/tags?post=46154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}