{"id":48126,"date":"2023-07-18T08:41:44","date_gmt":"2023-07-18T08:41:44","guid":{"rendered":"https:\/\/peymantaeidi.net\/stem-cell\/?p=48126"},"modified":"2023-07-18T09:00:11","modified_gmt":"2023-07-18T09:00:11","slug":"dna-origami-templates-used-to-control-virus-assembly","status":"publish","type":"post","link":"https:\/\/peymantaeidi.net\/stem-cell\/2023\/07\/18\/dna-origami-templates-used-to-control-virus-assembly\/","title":{"rendered":"DNA \u201cOrigami\u201d Templates Used To Control Virus Assembly"},"content":{"rendered":"
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Griffith University researchers have played a key role in using DNA \u2018origami\u2019 templates to control the way viruses are assembled.<\/p>\n

The global team behind the research, published in Nature Nanotechnolog<\/em>y, developed a way to direct the assembly of virus capsids \u2013 the protein shell of viruses – at physiological conditions in a precise and programmable manner.<\/p>\n

Dr Frank Sainsbury and Dr Donna McNeale from the Griffith Institute for Drug Discovery were part of the research team and said forcing viruses to assemble onto DNA folded into different shapes \u201clike origami\u201d was a question that this project answered.<\/p>\n

\u201cWe achieved control over the virus protein shape, size and topology by using user-defined DNA origami nanostructures as binding and assembly platforms, which became embedded within the capsid,\u201d Dr Sainsbury said.<\/p>\n

\u201cThe virus protein coatings could shield the encapsulated DNA origami from degradation.<\/p>\n

\u201cThis activity is more like wrapping a present \u2013 the virus proteins deposit on top of the different shape that is defined by the DNA origami shape.<\/p>\n

\u201cAnd different virus proteins are like different wrapping paper, which would be relevant to different uses of the coated DNA origami.\u201d<\/p>\n

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Precise control over the size and shape of virus proteins would have advantages in the development of new vaccines and delivery systems.<\/p>\n

\u201cBut current tools to control the assembly process in a programmable manner were elusive,\u201d Dr McNeale said.<\/p>\n

\u201cOur approach is also not limited to a single type of virus capsid protein unit and can also be applied to RNA\u2013DNA origami structures to pave way for next-generation cargo protection and targeting strategies.\u201d<\/p>\n

Currently, Dr Sainsbury and his team are working on gaining a more in-depth understanding of how different viruses self-assemble and how they can be used to encapsulate different cargoes.<\/p>\n

This will allow them to design and modify further virus-like particles for a range of uses. For example, they discovered that one virus found in mice is able to carry protein cargoes through inhospitable environments and into a specific subcellular compartment in human cells.<\/p>\n

\u201cWith the enormous existing design space among viruses that could be used as carriers, there is still much to learn from studying them. We\u2019ll continue to push the boundaries of how virus-like particles can assemble and what can be learned from using them as medicine transporters, vaccines and biochemical reaction vessels,\u201d Dr Sainsbury said.<\/p>\n

The next stage of the GRIDD team\u2019s research will use this approach to look at why viruses don\u2019t assemble into different shapes themselves.<\/p>\n

The research \u2018DNA-origami-directed virus capsid polymorphism\u2019 has been published in Nature Nanotechnology<\/em>.<\/p>\n

Reference: <\/b>Seitz I, Saarinen S, Kumpula EP, et al. DNA-origami-directed virus capsid polymorphism. <\/span>Nat Nanotechnol<\/i>. 2023. doi: <\/span>10.1038\/s41565-023-01443-x<\/span><\/a><\/p>\n

This article has been republished from the following materials.<\/a> Note: material may have been edited for length and content. For further information, please contact the cited source.<\/span><\/i><\/p>\n

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